000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Condensed Consolidated Balance Sheets (Current Period Unaudited) link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Condensed Consolidated Balance Sheets (Current Period Unaudited) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Condensed Consolidated Statements of Shareholders' Deficit (Unaudited) link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Condensed Consolidated Statements of Cash Flow (Unaudited) link:calculationLink link:definitionLink link:presentationLink 006 - Statement - Condensed Consolidated Statements of Cash Flow (Unaudited) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note 1 - Business and Nature of Operations link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note 2 - Basis of Presentation link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note 3 - Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note 4 - Other Financial Information link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note 5 - Inventories link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note 6 - Fair Value Measurements link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note 7 - Investments link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note 8 - Property and Equipment link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note 9 - Prepaid Forward Obligation link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note 10 - Long-term Debt link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note 11 - Leases link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note 12 - Revenue From Product Sales link:calculationLink link:definitionLink link:presentationLink 019 - Disclosure - Note 13 - License and Collaboration Agreements link:calculationLink link:definitionLink link:presentationLink 020 - Disclosure - Note 14 - Shareholders' Equity link:calculationLink link:definitionLink link:presentationLink 021 - Disclosure - Note 15 - Share-based Compensation link:calculationLink link:definitionLink link:presentationLink 022 - Disclosure - Note 16 - Income Taxes link:calculationLink link:definitionLink link:presentationLink 023 - Disclosure - Note 17 - Related Parties link:calculationLink link:definitionLink link:presentationLink 024 - Disclosure - Note 18 - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 025 - Disclosure - Note 19 - Subsequent Events link:calculationLink link:definitionLink link:presentationLink 026 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 027 - Disclosure - Note 3 - Significant Accounting Policies (Tables) link:calculationLink link:definitionLink link:presentationLink 028 - Disclosure - Note 4 - Other Financial Information (Tables) link:calculationLink link:definitionLink link:presentationLink 029 - Disclosure - Note 5 - Inventories (Tables) link:calculationLink link:definitionLink link:presentationLink 030 - Disclosure - Note 6 - Fair Value Measurements (Tables) link:calculationLink link:definitionLink link:presentationLink 031 - Disclosure - Note 7 - Investments (Tables) link:calculationLink link:definitionLink link:presentationLink 032 - Disclosure - Note 8 - Property and Equipment (Tables) link:calculationLink link:definitionLink link:presentationLink 033 - Disclosure - Note 9 - Prepaid Forward Obligation (Tables) link:calculationLink link:definitionLink link:presentationLink 034 - Disclosure - Note 10 - Long-term Debt (Tables) link:calculationLink link:definitionLink link:presentationLink 035 - Disclosure - Note 11 - Leases (Tables) link:calculationLink link:definitionLink link:presentationLink 036 - Disclosure - Note 12 - Revenue From Product Sales (Tables) link:calculationLink link:definitionLink link:presentationLink 037 - Disclosure - Note 15 - Share-based Compensation (Tables) link:calculationLink link:definitionLink link:presentationLink 038 - Disclosure - Note 2 - Basis of Presentation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 039 - Disclosure - Note 3 - Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 040 - Disclosure - Note 3 - Significant Accounting Policies - Useful Lives of Property and Equipment (Details) link:calculationLink link:definitionLink link:presentationLink 041 - Disclosure - Note 4 - Other Financial Information - Accounts Payable and Accrued Expense (Details) link:calculationLink link:definitionLink link:presentationLink 042 - Disclosure - Note 4 - Other Financial Information - Interest and Other Income (Expense), Net (Details) link:calculationLink link:definitionLink link:presentationLink 043 - Disclosure - Note 5 - Inventories (Details Textual) link:calculationLink link:definitionLink link:presentationLink 044 - Disclosure - Note 5 - Inventories - Inventories (Details) link:calculationLink link:definitionLink link:presentationLink 045 - Disclosure - Note 6 - Fair Value Measurements - Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 046 - Disclosure - Note 7 - Investments (Details Textual) link:calculationLink link:definitionLink link:presentationLink 047 - Disclosure - Note 7 - Investments - Summary of Marketable Securities (Details) link:calculationLink link:definitionLink link:presentationLink 048 - Disclosure - Note 7 - Marketable Securities - Fair Values of Marketable Securities by Contractual Maturity (Details) link:calculationLink link:definitionLink link:presentationLink 049 - Disclosure - Note 8 - Property and Equipment (Details Textual) link:calculationLink link:definitionLink link:presentationLink 050 - Disclosure - Note 8 - Property and Equipment - Property and Equipment (Details) link:calculationLink link:definitionLink link:presentationLink 051 - Disclosure - Note 9 - Prepaid Forward Obligation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 052 - Disclosure - Note 9 - Prepaid Forward Obligation - Activity in the Carrying Value of the Prepaid Forward Liability (Details) link:calculationLink link:definitionLink link:presentationLink 053 - Disclosure - Note 10 - Long-term Debt (Details Textual) link:calculationLink link:definitionLink link:presentationLink 054 - Disclosure - Note 10 - Long-term Debt - Long Term Debt (Details) link:calculationLink link:definitionLink link:presentationLink 055 - Disclosure - Note 11 - Leases (Details Textual) link:calculationLink link:definitionLink link:presentationLink 056 - Disclosure - Note 11 - Leases - Components of Lease Cost (Details) link:calculationLink link:definitionLink link:presentationLink 057 - Disclosure - Note 11 - Leases - Amounts of Assets and Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 058 - Disclosure - Note 11 - Leases - Supplemental Information Related to Leases (Details) link:calculationLink link:definitionLink link:presentationLink 059 - Disclosure - Note 11 - Leases - Maturities of Lease Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 060 - Disclosure - Note 11 - Leases - Undiscounted Cash Flows to be Received Under Sublease (Details) link:calculationLink link:definitionLink link:presentationLink 061 - Disclosure - Note 12 - Revenue From Product Sales - Net Product Sales (Details) link:calculationLink link:definitionLink link:presentationLink 062 - Disclosure - Note 12 - Revenue From Product Sales - Sales Reserves Activity (Details) link:calculationLink link:definitionLink link:presentationLink 063 - Disclosure - Note 13 - License and Collaboration Agreements (Details Textual) link:calculationLink link:definitionLink link:presentationLink 064 - Disclosure - Note 14 - Shareholders' Equity (Details Textual) link:calculationLink link:definitionLink link:presentationLink 065 - Disclosure - Note 15 - Share-based Compensation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 066 - Disclosure - Note 15 - Share-based Compensation - Effect of Share-based Compensation On the Condensed Consolidated Statements of Operations (Details) link:calculationLink link:definitionLink link:presentationLink 067 - Disclosure - Note 16 - Income Taxes (Details Textual) link:calculationLink link:definitionLink link:presentationLink 068 - Disclosure - Note 17 - Related Parties (Details Textual) link:calculationLink link:definitionLink link:presentationLink